Identification of coagulation-related hub genes in ischemic stroke based on bioinformatics integration analysis and investigation of their immune regulatory mechanisms.

ABSTRACT:

Background

Ischemic stroke (IS) is a cerebrovascular disease resulting from insufficient blood supply to specific areas of the brain, often due to atherosclerosis and thrombosis. While the association between polymorphisms in coagulation-related genes (CRGs) and thrombosis has been suggested, the precise relationship between CRGs and IS remains unclear and requires further exploration.

Methods

This study utilized IS-related datasets (GSE16561, GSE9877, GSE58294, GSE224273) and CRGs to identify differentially expressed genes (IS-DEGs) through differential expression analysis. Differentially expressed coagulation-related genes (DE-CRGs) were determined by overlapping CRGs and IS-DEGs. Machine learning models, including random forest, gradient boosting decision trees, and suppo

SUBMITTER: Li H 

PROVIDER: S-EPMC12729232 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature