Forensic utilization of NGS-STRs and evaluation of system efficacy for different kinship identifications.

ABSTRACT:

Background

The accurate identification of complex kinship relationships remains a significant challenge in forensic practice. Traditional kinship identification methods, which primarily rely on length polymorphisms of short tandem repeats (STRs), often face difficulty in achieving sufficient discriminatory power for complex relationships due to the limited genetic information they provide. While next-generation sequencing (NGS) enables the detection of allelic sequence polymorphisms within STRs, its practical value for different kinship analyses in specific populations requires comprehensive evaluation. To this end, the present study investigated the genetic polymorphisms of 52 STRs, with a focus on both length and sequence variations, aiming to evaluate the system efficacy and for

SUBMITTER: Xu H 

PROVIDER: S-EPMC12729311 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature