Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis.

ABSTRACT: The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a hierarchical structure and high stability, Pickering emulsions have demonstrated significant advantages in enhancing the bioavailability of encapsulated bioactive compounds. However, the specific role of their inherent flexibility in modulating interactions with the intestinal barrier and influencing delivery efficiency remains poorly understood. In this study, a flexible Pickering emulsion (FPPE) stabilized by chitosan nanoparticles was developed for encapsulating epigallocatechin gallate, aiming to investigate the role and underlying mechanism of its flexible st

SUBMITTER: Lv J 

PROVIDER: S-EPMC12729323 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature