Association Among Sperm Adiponectin, DNA Fragmentation, Oxidative Stress and Metabolites in Male Infertility.

ABSTRACT: Infertility is a widespread global problem, with a male factor contributing to approximately 40-50% of cases. Several studies have investigated the involvement of adipokines in reproductive functions, but only a few have investigated their role in the male reproductive component. Collectively, adipokines are present in human sperm and most of them are expressed in the male genital tract. Some authors report that adiponectin, in contrast with other adipokines such as resistin or chemerin, has a positive effect on spermatogenesis. Although the pathophysiological role of adipokines in sperm is not yet fully understood, they could influence sperm functionality and could be potential biomarkers of male fertility. High levels of sperm DNA fragmentation have been associated with several adverse r

SUBMITTER: Militello R 

PROVIDER: S-EPMC12729378 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature