Ovatifolin Purified from <i>Leptocarpha rivularis</i> Induces Cell Death in A375 and A2058 Melanoma Cancer Cells.

ABSTRACT: Skin cancer is increasing worldwide, with melanoma being its most aggressive and lethal form due to its high metastatic potential. Despite therapeutic advances, drug resistance remains a challenge, highlighting the need to explore new anticancer agents. Leptocarpha rivularis is a native plant of Chile, locally called "Palo negro", and is traditionally used in medicine by the Mapuche people. L. rivularis produces bioactive germacrene sesquiterpenoids with cytotoxic, antioxidant, anti-inflammatory and anti-angiogenic properties. This study reports for the first time the isolation of ovatifolin from aerial parts of L. rivularis and its identification by NMR and X-ray diffraction, together with its antiproliferative activity against two melanoma cell lines. The results sho

SUBMITTER: Burgos V 

PROVIDER: S-EPMC12729485 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature