Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms.

ABSTRACT: Mismatch negativity (MMN) has been frequently used to assess auditory processing and change detection in autism spectrum disorder (ASD), but findings have been fairly inconsistent. To address this issue, we conducted a systematic review and meta-analysis of MMN amplitude (76 effect sizes) and latency (62 effect sizes) in ASD to identify factors contributing to this heterogeneity and to interpret findings within the predictive coding framework. While residual heterogeneity remained, significant effects of the interaction between age group and design type (unifeature vs. multifeature, i.e., one or several types of deviants) and deviant type were found for MMN amplitude. In multifeature designs, autistic children and adolescents exhibited reduced MMN amplitudes compared to neurotypical peers

SUBMITTER: Sapey-Triomphe LA 

PROVIDER: S-EPMC12729487 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature