Artificial Intelligence Driven Innovation: Advancing Mesenchymal Stem Cell Therapies and Intelligent Biomaterials for Regenerative Medicine.

ABSTRACT: Artificial intelligence (AI) is revolutionizing regenerative medicine, particularly in advancing mesenchymal stem cell (MSC) therapies and smart biomaterials. This review highlights AI's role in two core areas: First, at the biological level, AI can be used to predict MSC differentiation, immunomodulatory function, and therapeutic potential by analyzing multi-omics and imaging data, deciphering heterogeneity and improving precision. For instance, deep learning models based on MSCs' morphology can successfully predict the differentiation propensity and uncover the regulatory networks underlying the intrinsic heterogeneity. Second, in engineering, AI shifts material design from trial-and-error to data-driven approaches. Machine learning models correlate material parameters with biological pr

SUBMITTER: Huang M 

PROVIDER: S-EPMC12729526 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature