Alkaloids isolated from Scutellaria Barbata D. Don trigger apoptosis and inhibit migration by modulating the p38-p53 pathway in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is a widely prevalent gynecological malignancy associated with significant morbidity and mortality. Scutellaria barbata D. Don (SB), a traditional Chinese medicine, has been reported to have diverse biological effects, including anti-ovarian cancer effects. However, the specific effects and underlying mechanism of the alkaloid fraction, the active fraction isolated from SB, in ovarian cancer remain unclear. This study aimed to explore the anti-tumor effects and underlying mechanisms of the alkaloid fraction of Scutellaria barbata D. Don (SBA) in ovarian cancer.

Methods

SBA was extracted by alcohol solvent extraction, and its chemical composition was analyzed using chromogenic reaction and high-pressure liquid chromatography-quadrupole time-of-flight

SUBMITTER: Gao B 

PROVIDER: S-EPMC12729567 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature