Methanol Extract from <i>Ranunculus repens</i> L. Down-Regulated Galectins 4 and 9, and Mitigated Chronic Pancreatitis in an Experimental Rat Model.

ABSTRACT: Chronic pancreatitis (CP) is a progressive fibro-inflammatory disease in which oxidative stress (OS) promotes pancreatic stellate cells activation and fibrosis. Ranunculus repens L. (R. repens) has been used in Algerian traditional medicine to treat conditions like hepatitis and diabetes. Galectins are β-galactoside-binding lectins implicated in several pathological processes, including inflammation. This study aimed to analyse the chemical composition and evaluate the protective effects of R. repens methanol extract (RRME) in an experimental CP model, as well as in cultured pancreatic cells. CP was induced by intraperitoneal injections of L-arginine in rats. The pancreas was examined histopathologically, using hematoxylin and eosin, and picrosirius red staining. OS ma

SUBMITTER: Khenchil A 

PROVIDER: S-EPMC12729588 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature