Chemical Characterization and Bio-Screening of Neuroprotective Potential of Brazilian Brown Seaweed <i>Canistrocarpus cervicornis</i> in 6-OHDA-Induced Neurotoxicity Model.

ABSTRACT: Brazilian native seaweed Canistrocarpus cervicornis (Ochrophyta, Dictyotaceae) is recognized for its chemodiversity, particularly cyclic diterpenes and polysaccharides, yet its relevance to neurological disorders remains unexplored. This study evaluated the neuroprotective potential of a hydroethanolic extract (ECCH), its polar fraction (CCFPol), a dichloromethane extract (ECCD), and eight derived fractions (CCF1-2, CCF3, CCF4, CCF5-6, CCF7, CCF8-10, and CCF11-15). Cytotoxicity was evaluated in SH-SY5Y neuroblastoma cells, and neuroprotection was examined against 6-OHDA-induced toxicity. The mitochondrial membrane potential, ROS and H₂O₂ generation assays were conducted to explore the mechanisms underlying the observed effects. Among the key findings, the CCF3

SUBMITTER: Dos Santos TC 

PROVIDER: S-EPMC12729634 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature