Ginseng Oligopeptides Promote Longevity and Enhance Stress Resistance in <i>Caenorhabditis elegans</i> via the DAF-16/FOXO Pathway.

ABSTRACT: Background: Ginseng oligopeptides (GOPs), small bioactive peptides with potent antioxidant capacity and high bioavailability, have shown promise in promoting healthy aging; however, their underlying molecular mechanisms remain largely unexplored. Methods: Using the model organism Caenorhabditis elegans (C. elegans), we comprehensively evaluated the anti-aging effects of GOPs on lifespan, locomotion, oxidative stress, and gene expression. Integrated phenotypic assays and transcriptomic analyses were conducted to elucidate GOP-mediated molecular mechanisms. The transgenic strain TJ356 (DAF-16::GFP) and the loss-of-function mutant CF1038 [daf-16(mu86)] were employed to functionally validate the role of the DAF-16/FOXO pathway. Results: GOP supplementa

SUBMITTER: Du Q 

PROVIDER: S-EPMC12729657 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature