Biomarkers and Mechanisms of Male Infertility: Evaluation of Antioxidant Enzymes and Arachidonic Acid Derivatives in Seminal Plasma from Fertile and Infertile Men.

ABSTRACT: Male infertility accounts for approximately 50% of reproductive failures, yet its diagnosis and understanding of underlying mechanisms remain limited. The present observational case-control study aimed to examine seminal plasma concentrations of prostaglandin E₂ (PGE₂), 6-keto-prostaglandin F_1α (6-keto-PGF_1α), F₂-isoprostane, superoxide dismutase 1 (SOD₁), glutathione peroxidase 1 (GPX₁), nitric oxide synthase 1 (NOS₁), and their ratios, in fertile (n = 22, aged 24-45) and infertile (n = 250, aged 21-47) men, including analyses across specific infertile subgroups, using ELISA assays. Overall, no significant differences were observed between fertile and infertile men. However, subgroup analyses revealed

SUBMITTER: Rodak K 

PROVIDER: S-EPMC12729684 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature