Accounting for Endoscopic Screening in Colorectal Cancer Risk Models.

ABSTRACT:

Background

Colorectal cancer risk models routinely adjust for endoscopic screening because of (i) possible confounding with other risk factors and (ii) possible alteration of the natural history of the disease due to adenoma detection and removal.

Methods

In this study, we defined a subject as screen-covered (SC) if a colonoscopy was performed in the past 10 years and not screen-covered (NSC) otherwise. We created colorectal cancer risk models separately for SC and NSC subjects (HRSC, HRNSC) and then obtained a screening-coverage adjusted HR estimate (HRfull) based on a weighted average of ln(HRSC) and ln(HRNSC), with weight equal to the proportion of SC person-time in the Nurses' Healh Study (NHS) population. We illustrate these methods on 45,538 participants of the NHS, fo

SUBMITTER: Wei EK 

PROVIDER: S-EPMC12729692 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature