Genetic disorders caused by consanguineous marriage in Radfan districts - Yemen.

ABSTRACT:

Background

Consanguineous marriage (≥ second cousins) is prevalent in Yemen (40-50%) and linked to increased genetic disorders. This study assesses its prevalence and health impacts in Radfan districts.

Methodology

A 2024 cross-sectional study of 1065 randomly selected households. Data were collected via validated questionnaires supplemented by medical records where available. Analyses included consanguinity rates, inbreeding coefficients (F), sociocultural factors, and clinically validated genetic disorders. Statistical analysis employed χ² tests, multivariable logistic regression (adjusted ORs), and Cohen's d for effect sizes.

Results

The consanguinity rate was 57.46%, significantly higher in rural (37.09%) than urban areas (20.38%). Wives with a university educatio

SUBMITTER: Mehdi MAH 

PROVIDER: S-EPMC12729813 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature