Serovar-Dependent Gene Regulation and Antimicrobial Tolerance in <i>Streptococcus suis</i> Biofilms.

ABSTRACT: Introduction:Streptococcus suis is a zoonotic pathogen of great relevance to the swine industry, characterized by high genetic diversity and multiple serovars (SVs) with varying clinical prevalence. Biofilm formation represents a key factor in its virulence, antimicrobial resistance and infection persistence. Methods: We integrated gene expression profiling of biofilm-associated genes by RT-qPCR and antimicrobial susceptibility in planktonic and mature biofilm against five antibiotics in S. suis field isolates belonging to SV1, SV2, SV7 and SV9. Results: Expression of quorum sensing and adhesion genes (luxS, fbps, sadP and srtA) was significantly higher in SV2, the poorest biofilm formers, and inversely correlated with biofilm

SUBMITTER: Delgado-Garcia M 

PROVIDER: S-EPMC12729831 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature