The Impact of Antimicrobial Therapy on the Development of Microbiota in Infants.

ABSTRACT: Background. The establishment and diversity of the gut microbiota during early childhood are fundamental for immune regulation and metabolic processes, with factors such as prematurity, delivery method, antibiotic treatment, and breastfeeding significantly impacting microbiome development and potential health outcomes. Objectives/Methods. This comparative study examined the gut microbiota composition in children aged 6-8 and 9-12 months, born via spontaneous labor at ≥38 weeks' gestation, who either did not receive antibacterial therapy or required beta-lactam antibiotics. The composition of the colonic microbiota was analyzed in these fecal samples using a quantitative real-time PCR (qRT-PCR). Results. Significant differences in microbiota composi

SUBMITTER: Priputnevich T 

PROVIDER: S-EPMC12729859 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature