Investigating the Dynamic Variation of Skin Microbiota and Metabolites in Bats During Hibernation.

ABSTRACT: Pseudogymnoascus destructans (Pd) invades the skin tissue of bats, leading to severe population declines. The skin microbiome plays a crucial role in protecting hosts from fungal infection and exhibits pronounced spatiotemporal dynamics in its structure and function. Meanwhile, metabolites derived from microbial communities reflect the host physiological state and participate in microbe-pathogen interactions. In this study, we investigated the spatiotemporal dynamics of skin bacterial communities and metabolites during hibernation in Rhinolophus ferrumequinum by integrating 16S rRNA sequencing with untargeted metabolomics and experimentally verified the antifungal effects of microbially derived potential metabolites against Pd. Our results revealed that the stru

SUBMITTER: Wang F 

PROVIDER: S-EPMC12729892 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature