Untargeted UHPLC-HRMS Metabolomic Profiling of <i>Cornus mas</i> L. Fruits: Impact of Conventional and Emerging Extraction Methods on Phenolic Composition and Bioactivity.

ABSTRACT: A growing number of studies evaluated cornelian cherry (Cornus mas L.) fruits due to their rich phenolic profile. It is obvious that the efficient recovery of these compounds depends on the extraction method used. Thus, this study aimed at comparing conventional (maceration, decoction) and non-conventional (ultrasound-assisted [UAE], enzyme-assisted [EAE]) extractions. Two novel aspects were characterized: the first application of EAE for cornelian cherry fruit phenolic recovery and the use of untargeted UHPLC-HRMS metabolomics. Untargeted UHPLC-HRMS profiling in positive electrospray ionization mode annotated 342 compounds, the broadest chemical analysis of C. mas fruits reported to date, followed by a semi-quantitative assessment of main phenolic compound subclasses using r

SUBMITTER: Frumuzachi O 

PROVIDER: S-EPMC12729893 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature