Peri-Operative Dosage and Therapeutic Concentrations of Cefazolin Administered for Surgical Site Infection Prophylaxis in Elective Surgery-A Systematic Review.

ABSTRACT: Background/Objectives: Cefazolin is commonly administered for surgical antibiotic prophylaxis. This review aims to examine whether target unbound plasma and tissue cefazolin concentrations are reached following prophylactic administration across multiple surgical subtypes. The primary outcome was a lower limit of cefazolin concentration variability (mean-SD, lower quartile, or lower range) in unbound plasma and/or tissue > 2 mg·L^-1, the epidemiological cut-off (ECOFF) value for Staphylococcus aureus at skin incision and/or closure. Methods: Prisma 2020 guidelines were followed, and the protocol is registered in PROSPERO (CRD42021080289). A literature search using MEDLINE (PubMed), Embase, CENTRAL, CINAHL, and further databases was performed to identify studi

SUBMITTER: Ryan R 

PROVIDER: S-EPMC12730041 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature