A Universal and Single-Step (De)Molding Sorting Chip Integrating Inertial and Deterministic Lateral Displacement Units.

ABSTRACT: Serum tests are valuable sources of information for disease diagnosis. Conventional whole blood cell separation requires many processing steps, including centrifugation, fractionation, lysis, and dilution, and is therefore complex and time consuming. To address the need for the efficient separation of blood cells for on-chip rapid serum assays, we developed a microfluidic chip integrating inertial sorting and deterministic lateral displacement. This chip consists of a helical structure and a deterministic lateral displacement triangular microcolumn array for rapid and efficient separation of blood cells from whole blood samples. After separation, the supernatant is extracted at the exit for subsequent testing or directed to serum test units directly integrated in the chip. Here, the lamina

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12730075 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature