Guava Leaf Extract as a Sustainable Preservative Alternative in Semi-Solid Pharmaceuticals: Efficacy and Stability Assessment.

ABSTRACT: Background: Natural alternatives are becoming more popular as a result of health risks associated with synthetic preservatives in pharmaceuticals. Because of its antibacterial properties, Psidium guajava (L.) leaf extract is a practical choice for sustainable preservation. Objectives: The aim of this research is to evaluate the efficacy of Psidium guajava (L.) leaf extract as a 10% (w/w) natural preservative in five different base formulations: creams (clotrimazole cream, permethrin cream, and gentamicin cream) and gels (indomethacin emulgel and ibuprofen gel). Methods: Over the course of 28 days, antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Aspergillus brasiliensis</

SUBMITTER: Imtara H 

PROVIDER: S-EPMC12730129 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature