Posterior Cortical Atrophy: Altered Language Processing System Connectivity and Its Implications on Language Comprehension and Production.

ABSTRACT: Background: Posterior cortical atrophy (PCA) patients typically show progressive visual decline, although language impairment can be a prominent feature. Previous studies have explored language connectivity impairment in PCA; not much is known about the exact nature of language processing disruptions in PCA. Methods: Thirty-seven PCA patients were compared with 39 cognitively unimpaired (CU) individuals. Functional connectivity was evaluated for the language processing system, which consisted of language, perceptual, motor, and cognitive networks. Linear regression was performed to compare within- and between-network connectivity across networks and within the language network in PCA compared to CU individuals. Relationships between language network connectivity, clinical per

SUBMITTER: Singh-Reilly N 

PROVIDER: S-EPMC12730223 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature