Morphofunctional Features of the Immune System Response to Sublethal Hypoxic Load in Hypoxia-Tolerant and Hypoxia-Susceptible Animals.

ABSTRACT: Background/Objectives: The most commonly used method for determining tolerance to oxygen deficiency is applying a sublethal hypoxic load (SHL) in a decompression chamber at an altitude of 11,500 m. The aim of this study was to identify the morphofunctional characteristics of the immune system's response to SHL in animals with different tolerances to oxygen deficiency. Methods: This study was conducted on male Wistar rats. Resistance to SHL was determined at a critical altitude (11,500 m) once in a decompression chamber. To study the features of the reaction to SHL, morphological and morphometric methods, flow cytometry, and real-time PCR were used. Results: One month after SHL, rats susceptible to hypoxia, in comparison with tolerant ones, demonstrated higher numbers o

SUBMITTER: Kirillova M 

PROVIDER: S-EPMC12730225 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature