Analysis of the Correlation Between Cuproptosis and Instability of Atherosclerotic Plaques.

ABSTRACT: Background/Objectives: Cuproptosis, a newly discovered form of programmed cell death, is dependent on the regulation of copper ions. The roles and mechanisms of cuproptosis-related genes (CRGs) in the instability of atherosclerotic plaques are still unclear. Methods: GEO microarray datasets were downloaded to analyze stable and unstable human carotid artery plaques. Differential expression analysis was performed to screen for CRGs from the Molecular Signatures Database (MSigDB). Machine learning was applied to identify key genes and cluster unstable plaque genes. The identified genes were verified by immunohistochemistry (IHC) of human carotid plaque samples, and the effect of ATOX1 on cuproptosis was detected in human umbilical vein endothelial cells (HUVEC). Results:

SUBMITTER: Muhetaer M 

PROVIDER: S-EPMC12730235 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature