Exercise as a Promising Adjunct Treatment for Methamphetamine Addiction: Advances in Understanding Neuroplasticity and Clinical Applications.

ABSTRACT: Background: Methamphetamine (Meth) addiction, with its high relapse rates, poses a significant global challenge. Conventional therapies remain inadequate, highlighting the need for effective adjunctive treatments. Objective: This review synthesises evidence to propose a novel 'Exercise Modality-Neural Target-Rehabilitation Stage' integration model, elucidating how aerobic, resistance, and mind-body exercises differentially target specific neural pathways to ameliorate cognitive deficits, emotional dysregulation, and craving in Meth use disorder. Methods: A narrative synthesis of 84 studies (up to March 2025) from PubMed, Web of Science, and CNKI was conducted, focusing on the neurobiological basis and clinical application of exercise interventions. Results: The

SUBMITTER: Li Y 

PROVIDER: S-EPMC12730288 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature