Synaptic Changes in Mice Lacking Alpha- and Gamma-Synucleins.

ABSTRACT: Background: Alpha-synuclein is a key protein involved in the pathogenesis of Parkinson disease (PD). Its intermediate aggregated forms disturb the normal function of dopaminergic (DA) neurons. Furthermore, the loss of intraneuronal connections may precede nerve cell death in PD. Disturbance of presynaptic functions of alpha-synuclein and its family members, beta- and gamma-synuclein, can apparently be the first step in nigrostriatal system dysfunction. Based on their structure homology and subcellular localization, the three synuclein proteins could have overlapping functions. This also indicates necessitates to study each protein in isolation. Methods: We have established a unique mouse line with conditional knockout (KO) of alpha-synuclein inactivation on the background of

SUBMITTER: Krayushkina AM 

PROVIDER: S-EPMC12730289 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature