Molecular Evolution of the NLR Gene Family Reveals Diverse Innate Immune Strategies in Bats.

ABSTRACT: Bats, as the world's second-largest mammalian order, have garnered significant attention for their ability to harbor numerous viruses without exhibiting disease symptoms. Nucleotide-binding domain and leucine-rich repeat-containing receptors (NLRs) are crucial components of the immune system. This study conducted an evolutionary analysis of the NLR gene family across 26 bat species to investigate the molecular mechanisms underlying their role in viral resistance under high viral load pressure. We identified gene duplication events in multiple genes. The NLR gene family exhibited high conservation throughout evolution, which may contribute to the occurrence of gene duplication. This conserved genomic structure also ensures functional stability, safeguarding bats' antiviral resistance. Most

SUBMITTER: Liu G 

PROVIDER: S-EPMC12730308 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature