Survival Impact of Cytoreductive Surgery in FIGO Stage IVB Endometrial Cancer: A Population-Based Study.

ABSTRACT: Background: The impact of cytoreductive surgery on survival in patients with FIGO stage IVB endometrial cancer remains controversial. This study aimed to evaluate the independent effect of surgery within contemporary multimodal treatment strategies using a large population-based registry. Patients and methods: We conducted a multicenter retrospective analysis of 6582 patients with endometrial cancer recorded in the Saxony-Anhalt cancer registry between 2000 and 2020. After exclusions, 294 patients with FIGO stage IVB disease were included. Disease-free survival (DFS) was the primary outcome and overall survival (OS) the secondary outcome. Patients were initially categorized into three treatment groups: surgery only, non-surgical therapy, and combined multimodal therapy. To ad

SUBMITTER: Gennari P 

PROVIDER: S-EPMC12730323 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature