Blood Cell-Derived Inflammatory Indices in Diabetic Macular Edema: Clinical Significance and Prognostic Relevance.

ABSTRACT: Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. While VEGF-driven vascular permeability is central to its pathogenesis, inflammation plays a complementary and pivotal role in disease progression, morphological heterogeneity, and treatment response. Readily available blood cell-derived inflammatory indices, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), monocyte-to-high-density lipoprotein cholesterol ratio (MHR), monocyte-to-lymphocyte ratio (MLR), platelet-to-neutrophil ratio (PNR), and pan-immune-inflammation value (PIV), as well as platelet measures (MPV, PDW), have been investigated as low-cost markers of systemic inflammation in DME. Specifically, comparative stud

SUBMITTER: Lin C 

PROVIDER: S-EPMC12730579 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature