Heterogeneous Lineages of DNA Transposons Encode a TET/JBP Dioxygenase in Fungi.

ABSTRACT: Epigenetic DNA modification is a key component of the defense system against invading nucleic acids such as transposons. TET/JBP dioxygenases oxidize 5-methylcytosine and lead to its replacement by cytosine in mammals. Expansion of TET/JBP genes and their association with DNA transposons were previously reported in Basidiomycota fungi. In this study, a thorough bioinformatics investigation of TET/JBP genes revealed that diverse groups of DNA transposons have captured a TET/JBP dioxygenase in three lineages of fungi: Pucciniomycetes (rusts) and Agaricomycetes (mushrooms) in Basidiomycota, and Pezizomycetes (morels and truffles) in Ascomycota. TET/JBP genes encoded by DNA transposons can be classified into three types, designated as PU, AG, and PE here. The PU type is di

SUBMITTER: Kojima KK 

PROVIDER: S-EPMC12730594 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature