Endophenotype Research in Epilepsy Across Time.

ABSTRACT: Background/Objectives: Endophenotypes-quantifiable biological markers bridging genetic variations and clinical manifestations-have significantly evolved since their introduction to psychiatric genetics. This study presents the first comprehensive analysis of endophenotype research in epilepsy, examining validation frameworks, methodological approaches, and the potential for clinical translation. Methods: We employed a dual-methodological approach combining the bibliometric analysis with a systematic review and a meta-analysis. Literature searches in the Web of Science and Scopus databases (17 July 2025) employed comprehensive strategies that incorporated endophenotype and epilepsy terminology. In the bibliometric analysis, the 'Bibliometrix' R package (version 4.4.3 (R Core T

SUBMITTER: Yetkin O 

PROVIDER: S-EPMC12730710 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature