Randomised trial protocol to assess efficacy of modified olfactory training method for patients with postinfectious olfactory dysfunction.

ABSTRACT:

Introduction

This article outlines the research protocol for a multicentre, randomised, controlled study designed to evaluate the therapeutic effect of a modified olfactory training (MOT) based on bi-directional nasal drug delivery system for patients with postinfectious olfactory dysfunction (PIOD), and to compare its efficacy with conventional olfactory training (COT).

Methods and analysis

This is a multicentre study in which patients will be recruited from several participating hospitals. Patients will be divided into three groups: COT group using COT device, MOT group using MOT device, Control group without any intervention other than follow-up. The olfactory training (OT) intervention will last for 12 months. The primary outcome will be the improvement in olfactory abil

SUBMITTER: Xie J 

PROVIDER: S-EPMC12730742 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature