Safety of COVID-19 vaccines among pregnant individuals in Quebec, Canada: a population-based retrospective cohort study from the Canadian Immunization Research Network.

ABSTRACT:

Objective

To estimate the association between maternal COVID-19 vaccination during pregnancy and adverse neonatal and maternal outcomes.

Design

Population-based retrospective cohort study using a hospitalisation database linked with other health administrative databases.

Setting

Province of Quebec, Canada, from 1 May 2021 to 30 June 2023.

Participants

All singleton pregnancies resulting in a live birth or stillbirth at ≥20 weeks of gestation, excluding those with a conception date <42 weeks before the end of the study period.

Primary outcome measures

We used robust Poisson regression models to estimate adjusted risk ratios (aRRs) for chorioamnionitis, postpartum haemorrhage, caesarean delivery, preterm birth, very preterm birth, small for gestational age

SUBMITTER: Kiely M 

PROVIDER: S-EPMC12730766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature