Intraindividual cognitive function course over time in patients with systemic lupus erythematosus.

ABSTRACT:

Background

Cognitive impairment (CI) is one of the most common manifestations of neuropsychiatric systemic lupus erythematosus (SLE). This study aimed to characterise the course of CI over a 1-year period in patients with SLE and its associated factors.

Methods

175 adult SLE patients from the University of Toronto Lupus Clinic were assessed at baseline, 6 months and 12 months using the American College of Rheumatology Neuropsychological Battery. CI was classified based on standardised z-scores in cognitive domains. Patients were categorised as persistent-CI (CI at all three time-points; T0, T1 and T2), never-CI (no CI at any time-point) or fluctuating-CI (CI at 1-2 assessments). Sociodemographic, clinical, laboratory and medication data were collected at each visit. Patients

SUBMITTER: Tayer-Shifman OE 

PROVIDER: S-EPMC12730825 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature