Clinical and Molecular Characterization of Myeloid Sarcoma: A Systematic Review and Meta-Analysis.

ABSTRACT: Background/Objectives: Myeloid sarcoma (MS) is a rare extramedullary manifestation of myeloid blasts, with limited systematic data, particularly regarding molecular (NGS) concordance between MS tissue and bone marrow. We hypothesized that clonal heterogeneity may exist between these sites due to their distinct biological environments. Methods: We conducted a systematic review and meta-analysis of 85 studies encompassing 7241 MS patients, to evaluate clinical characteristics, mutational profiles, treatment patterns, and outcomes. Mutational concordance or discordance between MS and bone marrow was assessed in a subset of 112 patients. Results: Male predominance (59%) and skin/soft tissue localization (31%) were most common. NPM1 (25%) and FLT3 (20%) were t

SUBMITTER: Padmanabhan DS 

PROVIDER: S-EPMC12730967 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature