Multi-Organ Toxicity of Combined PFOS/PS Exposure and Its Application in Network Toxicology.

ABSTRACT: Perfluorooctane sulfonate (PFOS) has been widely utilized in products such as cotton textiles, hydraulic oils, coatings, pharmaceuticals, cosmetics, etc. Now it is widely distributed in various environmental media, wildlife, and human bodies. Polystyrene (PS) as a kind of plastics, their products under the physical, chemical, and biological decomposition in the environment are widely distributed in the air, soil, oceans, surface water, and sediments. However, PS and PFOS often coexist in the environment, making the study of their combined exposure mechanisms more aligned with actual conditions. This research integrates network toxicology and molecular biology techniques to predict the toxicity and common differentially expressed gene enrichment pathways of PFOS and PS. This study investiga

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12730987 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature