Single-Cell Analysis Links C7+ Cancer-Associated Fibroblasts with Incomplete Resection in Platinum-Sensitive Relapsed Ovarian Cancer.

ABSTRACT: Background/Objectives: Achieving complete resection (R0) during secondary cytoreduction (SCR) is a pivotal prognostic factor for patients with platinum-sensitive relapsed ovarian cancer (PSROC). Methods: By integrating single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and functional assays on primary cells, we identified tumor microenvironment (TME) heterogeneity, particularly the presence of distinct subpopulations of cancer-associated fibroblasts (CAFs), as a critical determinant of surgical outcomes for SCR. Results: We characterized a previously unrecognized CAF-C7 subpopulation that was selectively enriched in tumors from non-R0 patients. Mechanistically, CAF-C7 promoted tumor cell migration, suppressed anoikis, and facilitated angiogenesis via the

SUBMITTER: Li L 

PROVIDER: S-EPMC12731083 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature