An Invisible Early Steatosis Phenotype Defined for a Large Population-Based Cohort.

ABSTRACT: Background: The current definition of metabolic dysfunction-associated steatotic liver disease (MASLD) relies on a classical assessment of steatosis via liver biopsy, with grades S0-S3 (5-100% fat) potentially underestimating low-grade steatosis. We propose a new, more sensitive classification based on magnetic resonance imaging-proton-density fat fraction (MRI-PDFF), splitting the existing S0 and S1 grades into three classes: new-S0, very early S1 (S1A), and later S1 (S1B). We aimed to determine whether these early S1A/S1B phenotypes differed clinically or biologically from the new-S0 grade using large population cohorts. Methods: We assessed the prevalence of the new MRI-PDFF-based grades in 29,252 healthy participants from the UK Biobank discovery cohort, 286 outpatients w

SUBMITTER: Poynard T 

PROVIDER: S-EPMC12731107 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature