Long-Term Alterations of Glucocorticoid Receptor Expression and CD4⁺ T Cells in Adolescent Rhesus Macaques Following Early-Life Adversity.

ABSTRACT: Child maltreatment (MALT) is a devastating form of early-life adversity (ELA) and a primary risk for mental and physical illness. It is difficult to disentangle postnatal caregiving effects from heritable factors. Here we investigated the long-term effects of maternal care using a cross-fostering design to control for biological/heritable factors on immune function and inflammation during adolescence in a translational and naturalistic macaque model of MALT. We studied the impact of MALT on the immunophenotype of peripheral blood mononuclear cells (PBMCs) and assessed glucocorticoid receptor expression and function during adolescence. MALT was associated with elevated expression of NR3C1, the gene that encodes for the glucocorticoid receptor, in PBMCs. Glucocorticoid receptor functi

SUBMITTER: Sanchez MM 

PROVIDER: S-EPMC12731112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature