Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians.

ABSTRACT: Ibrutinib (IB), a Bruton's tyrosine kinase (BTK) inhibitor, is widely used against B-cell malignancies. However, its adverse effects on stem cell-dependent processes and tissue homeostasis remain incompletely understood. Freshwater planarians possess pluripotent stem cells (neoblasts), which enable remarkable regeneration of various tissues, including the central nervous system. This makes them ideal in vivo models for studying chemical toxicity within a whole-organism context. Here, we utilized planarian Dugesia constrictiva to assess IB toxicity and elucidate its mechanisms, focusing on its impact on stem cell dynamics and regeneration. Our results demonstrated that exposure to IB at concentrations as low as 0.9 mg/L, far below clinical plasma levels, led to severe morphological a

SUBMITTER: Guo W 

PROVIDER: S-EPMC12731123 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature