Treatment Sequences in Patients with Metastatic Colorectal Cancer in Japan: Real-World Evidence of First- to Fifth-Line Treatments.

ABSTRACT: Background: The development of later-line drugs for metastatic colorectal cancer (mCRC) has expanded treatment options. However, real-world evidence of treatment sequences and transition rates from early- to later-line treatments are limited. Patients and methods: This was a retrospective study using hospital administrative data from patients in Japan who underwent colorectal cancer surgery or first-line treatment after January 2017. Transition rates were calculated and treatment sequences were summarized using a Sankey diagram. Logistic regression was performed to identify factors associated with the transition from second- to third-line treatment. Results: In total, 27,100 patients (median age: 69 years) were included in the study population. Transition rates to subs

SUBMITTER: Kagawa Y 

PROVIDER: S-EPMC12731131 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature