Atrazine Induces Reproductive Toxicity in an <i>In Vitro</i> Spermatogenesis (IVS) Model.

ABSTRACT: Background/Objectives: Atrazine (ATZ) is a widely used herbicide, and most studies of its reproductive toxicity have been conducted in vivo using animal models, where ATZ disrupts redox homeostasis, leading to male reproductive dysfunction. However, its molecular mechanisms of action in human spermatogenic cells remain poorly understood. Huntington's disease (HD), an autosomal dominant disorder caused by abnormal CAG repeat expansion in the HTT gene, exhibits heightened oxidative stress sensitivity and mitochondrial dysfunction, which may further impair reproductive function. This study investigated ATZ effects on human spermatogenesis using an in vitro spermatogenesis (IVS) model derived from human induced pluripotent stem cells (hiPSCs), focusing on Nrf2-media

SUBMITTER: Chaiyakit M 

PROVIDER: S-EPMC12731135 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature