Incretin-Related Pathology and Serum Exosome Detection in Experimental Alcohol-Related Brain Damage.

ABSTRACT: Alcohol's chronic neurotoxic and degenerative effects mediate alcohol-related brain damage (ARBD), which is marked by neurobehavioral, cognitive, and motor deficits. Major underlying abnormalities include impairments in signaling through the insulin and insulin-like growth factor (IGF) pathways, which regulate energy metabolism. This study examined the potential role of dysregulated incretin network-related mechanisms as mediators of ARBD and evaluated a non-invasive serum exosome (S-EV)-based approach for detecting brain abnormalities. Frontal lobe tissue and S-EVs isolated from Long-Evans adolescent rats maintained for 2 weeks on control or 24% ethanol (caloric) containing liquid diets (n = 8/group) were analyzed using multiplex magnetic bead-based enzyme-linked immunosorbent assays (ELI

SUBMITTER: de la Monte SM 

PROVIDER: S-EPMC12731142 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature