Exploring the interplay between diet, obesity, mental health, and the gut microbiota: the MIND-GUT intervention study, study protocol.

ABSTRACT:

Background

Obesity and mental health disorders often co-occur, contributing to individual suffering and healthcare costs. Diet plays a key role in both weight management and mental wellbeing and may influence these through its impact on the gut microbiota. However, the mechanisms linking diet, obesity, and mental health remain insufficiently understood.

Aim

We propose to conduct the MIND-GUT study in Sweden to evaluate feasibility as primary outcome (retention, adherence, and acceptability) of a 12-week dietary intervention based on the MIND diet and, as secondary outcomes, the influence of the latter on weight loss and mental wellbeing in adults with overweight and obesity [body mass index (BMI) ≥30 kg/m²]. The study will also explore changes in gut microbiota co

SUBMITTER: Gustafson D 

PROVIDER: S-EPMC12731245 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature