Multi-responsive nanocomposite hydrogel for synergistic photothermal-chemotherapy to prevent postoperative recurrence and metastasis of uveal melanoma.

ABSTRACT: Postoperative recurrence and metastasis remain major challenges in improving the prognosis of uveal melanoma (UM). Herein, we developed a chitosan-based injectable multi-responsive nanocomposite hydrogel (CPT NPs gel) for localized and synergistic photothermal-chemotherapy following tumor resection. This hydrogel co-encapsulates pH/GSH-responsive camptothecin-loaded nanoparticles (CPT NPs) and polydopamine, forming a porous, self-healing network that persists in vivo for over 28 days. Upon near-infrared (NIR) irradiation, the hydrogel rapidly elevates the local temperature to approximately 60 °C within 40 s, enabling efficient ablation of residual tumor tissue at the surgical site. Concurrently, CPT NPs are sustainably released from the hydrogel and enter systemic circulation, where they u

SUBMITTER: Guo Z 

PROVIDER: S-EPMC12731282 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature