Circulating Interleukin-6 as a Prognostic Biomarker for Mortality in Melioidosis: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Melioidosis, caused by Burkholderia pseudomallei, remains a major cause of sepsis-related mortality in tropical regions. Despite effective antimicrobial therapy, deaths frequently result from dysregulated host inflammation rather than uncontrolled bacterial replication. Interleukin-6 (IL-6), a key mediator of systemic inflammation, has been proposed as a prognostic biomarker in sepsis, but its predictive value in melioidosis has not been systematically evaluated. Methods: A systematic review and meta-analysis were performed following PRISMA 2020 guidelines (PROSPERO CRD420251152797). MEDLINE, Embase, and Scopus were searched from inception to 15 March 2025. Eligible studies included patients with culture-confirmed melioidosis reporting circulating IL-6 conc

SUBMITTER: Khemla S 

PROVIDER: S-EPMC12731466 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature