Extent of resection and its association with overall survival in newly diagnosed IDH wildtype glioblastoma treated with concomitant radiochemotherapy: a systematic review and meta-analysis.

ABSTRACT:

Background

Extent of resection (EOR) is a well-known prognostic factor in patients with newly diagnosed IDH-wildtype glioblastoma. However, reported survival times across resection categories vary between reports, and outcomes of submaximal or supramaximal resection remain less well defined.

Methods

We conducted a systematic review and meta-analysis on the association between EOR and overall survival (OS) in patients with newly diagnosed IDH-wildtype glioblastoma treated with chemoradiotherapy. Studies were included if OS was reported by EOR category. Risk ratios (RRs) for 1- and 2-year survival were pooled using a random-effects model. Study quality was assessed using the Newcastle-Ottawa Scale.

Results

Thirty-one studies involving 26,167 patients were included. Supr

SUBMITTER: Geens W 

PROVIDER: S-EPMC12731770 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature