Histological Outcomes of Alveolar Ridge Preservation Versus Spontaneous Healing Following Tooth Extraction: A Systematic Review and Meta-Analysis.

ABSTRACT: Objectives: This systematic review and meta-analysis aimed to evaluate histological outcomes of alveolar ridge preservation (ARP) compared to spontaneous healing after tooth extraction, focusing on the percentage of new bone formation and residual graft material. Materials and Methods: Randomized controlled trials (RCTs) assessing histomorphometric outcomes in humans were included. Eligible studies compared ARP using various graft materials to unassisted socket healing. Primary outcome was new bone formation (%); secondary outcome was residual graft material (%). Random-effects meta-analyses and subgroup analyses were conducted based on graft material type, membrane application, and healing duration. Risk of bias and certainty of evidence were assessed using the Cochrane RoB

SUBMITTER: Benekou I 

PROVIDER: S-EPMC12731776 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature