Inflammatory profiles of transdiagnostic symptom dimensions in healthy females.

ABSTRACT:

Background

Psychiatric disorders are increasingly conceptualised as heterogeneous categories with transdiagnostic underlying mechanisms that cut across multiple diagnoses and vary within a single diagnosis. Inflammation induced by psychosocial stress is one particularly potent example: previous research suggests that inflammatory profiles may correspond to symptom subgroups rather than traditional diagnostic categories. However, robust identification of transdiagnostic symptoms linked to specific inflammatory profiles remains rare. In this study, we examined the relationship between inflammatory profiles (at baseline and after a stress induction) and transdiagnostic symptom dimensions in females, who show higher prevalence of stress-related disorders such as anxiety and depression.

SUBMITTER: Smith AJ 

PROVIDER: S-EPMC12731786 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature