Multi-Omics Elucidation of Edulinine's Intervention Mechanism in Hypertensive Rats.

ABSTRACT: Hypertension is a cardiovascular disorder characterized by sustained elevation of arterial blood pressure, in which vascular dysfunction serves as a key initiating factor leading to target organ injury. The indole alkaloid edulinine (Edu) represents a potential therapeutic agent for hypertension, although its specific mechanisms remain unclear. This study investigated the protective effects of Edu on vascular endothelial injury in N-⁠nitro-⁠L-⁠arginine-induced hypertensive rats using physiological, biochemical, and histopathological assessments. Through integrated proteomic and metabolomic analyses, we examined Edu's effects on thoracic aortic tissue proteins and serum metabolic profiles to elucidate its molecular mechanisms. The results demonstrated that Edu exhibited superior antihyperte

SUBMITTER: Tao L 

PROVIDER: S-EPMC12731850 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature